Paternal age over 50 years decreases assisted reproductive technology (ART) success: A single UK center retrospective analysis

Introduction To study whether paternal age exerts an effect, independent of maternal age, on the outcomes fresh in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles. Semen quality deteriorates with increasing age; however, there is conflicting evidence for any impact may have outcome IVF/ICSI. Several retrospective and prospective cohort studies shown that increases miscarriage rate reduces live birth rate. Some no effect or Studies involving donor oocytes tended to show assisted reproductive technology (ART) outcomes. The at which exert a significant deleterious not known limit IVF/ICSI treatment. Material methods A single-center was carried out Centre Reproductive Genetic Health, London, UK. Included analysis were all couples primary secondary infertility undergoing cycles male partner produced semen sample cycle proceeded embryo transfer. All used oocytes—donor sperm, frozen leading storage including preimplantation genetic testing (PGT-A/PGT-M)—were excluded from analysis. clinical pregnancy Multivariate logistic regression as dependent variable class variables performed. Results During period 4833 cycles, 4271 men, eligible analysis; 1974/4833 (40.8%, 95% confiene intervals [CI] 39.5–42.2%) resulted birth. significantly lower proportion men over 51 years met World Health Organization criteria (56/133, [42.1%, CI 34.1–50.6]) compared under (2530/4138 [61.1%, 60.0–62.6]) (p = 0.001). Both retained multivariate model subgroups probability decreased 50 (odds ratio [OR] 0.674, 0.482–0.943) 0.021). Paternal predictor (OR 0.678, 0.369–1.250) 0.214). Conclusions affects chance achieving following ART. does independently affect risk There should be public health message delay fatherhood.